A blog by two chemists working in chemistry and chemical biology

Sunday, 24 March 2013

The Peterson olefination



There are many different ways to synthesise alkenes in organic synthesis. The problem in many cases, especially those in macrocycles or non-cyclic systems is getting good E/Z selectivity. Several methods are possible however, one of the simplest is the peterson olefination. The reaction allows control of E/Z selectivity by the conditions used to remove the silane.